Best Supplements for Women: Glow Through Perimenopause & Beyond

Struggling with energy dips, mood swings, or hot flashes? Discover the best evidence-based supplements for women—including perimenopause must-haves like vitamin D, magnesium, and phytoestrogens—to feel balanced and vibrant at any age.

1/19/2026

a group of pills or supplements on a surface
a group of pills or supplements on a surface

Supplements can be a helpful layer of support for women, especially during perimenopause and menopause—but they’re extras, NOT magic fixes. Think of them as backup singers to the main show: sleep, stress, food, movement, and regular check-ins with your doctor are especially important.

This is for education only, not personal medical advice. Always check with a healthcare professional, especially if you take medications, are pregnant, or have a medical condition.

Do Women Really Need Supplements?

Most women can get what they need from a well-balanced diet, BUT real life (busy schedules, stress, picky eating, heavy periods, midlife hormone shifts) often makes that tricky. That’s where a few supplements can help plus support energy, mood, bones, and hormones.

A few quick truths to keep in mind:

  • Supplements are lightly regulated compared to medications, so quality and dose can vary a lot between brands.

  • More is not better; megadoses of vitamins and minerals can cause side effects or interact with medications.

  • Look for third‑party testing seals like NSF, USP, or GMP when you’re choosing products.

Foundational Supplements For Most Women

These are “everyday basics” many women benefit from, depending on their diet and labs.

  • Multivitamin
    A simple women’s multivitamin can back you up on essentials like vitamin C, folate, iron (if needed), B vitamins, zinc, and more. Multivitamins are most useful as insurance for women who struggle to eat a varied diet or have specific restrictions (like vegan or very low‑calorie eating).

  • Vitamin D
    Vitamin D supports bone strength, immune health, and muscle function, and low levels are common in women, especially those living in colder climates or indoors a lot. Lower vitamin D is linked with weaker bones and muscle loss in midlife and older women, falling or fractures increase significantly.

  • Calcium
    Calcium, teamed up with vitamin D and weight-bearing exercise, is key for strong bones and prevention of osteoporosis. Women who avoid dairy or have low intake of calcium-rich foods sometimes need a supplement, while others may get enough through food alone.

  • Iron
    Iron can be helpful for women with heavy periods, pregnancy, or diagnosed iron deficiency, but it usually isn’t needed (and can be harmful) after menopause unless there’s a specific issue. Too much iron can cause digestive upset and, in excess, more serious health problems, so it’s best to supplement iron only when a lab test confirms you need it.

  • B vitamins
    B vitamins support energy metabolism, brain function, and red blood cell production and are especially important for women who are vegetarian or vegan. Many perimenopause formulas include B vitamins because they may help with fatigue and mood, especially when dietary intake is low.

Bonus Helpers: Gut, Muscle, Brain & Stress

As women move through different seasons of life, certain “extra” supplements can offer targeted benefits.

  • Omega‑3 fatty acids (fish oil or algae oil)
    Omega‑3s support heart health, brain function, and may help with inflammation and mood. They’re especially helpful if you rarely eat fatty fish like salmon, sardines, or mackerel.

  • Probiotics
    Probiotics may support digestion, immunity, and vaginal health, though strains and doses matter, and not all products are created equal. Getting a variety of fiber‑rich plant foods still matters more for gut health than any single pill.

  • Magnesium
    Magnesium supports muscle relaxation, sleep, blood sugar balance, and nervous system calm, and many women do not meet the recommended intake from diet alone. Some women find magnesium glycinate or citrate helpful for tension, sleep, and constipation, but high doses can cause diarrhea.

  • Creatine
    Creatine isn’t just for bodybuilders; research shows it can help women 40+ maintain muscle, strengthen bones, and possibly support brain health when combined with resistance training. Women tend to have 70–80% lower creatine stores than men, and those levels decline with age, so supplementation can be especially helpful in peri- and postmenopause. lifestyle medicine.

Supplements For Perimenopause & Menopause

Perimenopause (the hormonal roller coaster years before your period fully stops), oh yes..so fun lol and menopause (12 months with no period) bring changing hormone levels, hot flashes, sleep changes, mood swings, and bone changes. Many women look for “non‑hormonal” support in this stage, and some supplements can help with specific symptoms.

Evidence here is mixed; some women feel a big difference, others feel nothing. It’s smart to start low, keep your stack simple, and check in with your doctor about interactions—especially if you have a history of hormone‑sensitive cancers, blood clots or take blood thinners, antidepressants, or blood pressure meds.

Commonly Used Perimenopause & Menopause Supplements

  • Calcium & Vitamin D for bones
    During perimenopause and menopause, dropping estrogen speeds up bone loss, increasing the risk of osteoporosis and fractures. Calcium and vitamin D are widely recommended to support bone density, especially for women who do not get enough through food or sun.

  • Phytoestrogens (soy isoflavones, red clover)
    Phytoestrogens are plant compounds that act a bit like gentle estrogen in the body and are often used for hot flashes and night sweats.

  • Black cohosh
    Black cohosh is a popular herbal supplement marketed for hot flashes and mood changes, but research shows mixed results: some studies suggest benefit, while others show no significant effect. It may not be safe for women with certain liver conditions, so again, make sure you speek with your doctor before you start taking any new medication.

  • Maca
    Maca is a root often included in “hormone balance” blends and perimenopause formulas, and it is thought to help with energy, mood, and libido, though solid evidence is still limited. Many of the positive reports come from small studies or personal experience, so it falls into the “might help, not fully proven” category.​

  • Curcumin (turmeric extract)
    Curcumin has anti‑inflammatory properties, and some research suggests it may help with joint pain, brain fog, and mood in cyclical hormonal conditions. Since perimenopause can bring more aches and cognitive changes, curcumin may be a useful for some women.

  • Melatonin
    Melatonin may support sleep quality, in women who struggle with falling asleep or staying asleep, but most experts suggest using it for short periods pf time rather than as a permanent nightly fix. Perimenopausal sleep changes are often hormone‑driven, so melatonin may help.​

How To Choose & Use Supplements Safely

The supplement aisle can feel overwhelming, so let's simplify this:

  • Start with labs and lifestyle first. Before you start taking every supplement TikTok recommends, it’s smart to start with labs and lifestyle basics. Ask your healthcare provider about checking things like vitamin D, iron, and B12, along with any other markers that make sense for your body.

  • At the same time, focus on the foundations that actually move the needle during menopause: getting enough protein, doing strength training, prioritizing sleep, and managing stress. Supplements work best when they’re supporting a healthy routine—not trying to fix everything on their own.

  • Keep your menopause supplement stack simple. A lot of menopause supplements come loaded with long ingredient lists, herbs you’ve never heard of, and “proprietary blends” that don’t clearly show the dose. More isn’t always better.

A simpler, more effective approach is sticking to a high-quality multivitamin plus one or two symptom-focused supplements. For example, vitamin D paired with soy isoflavones for hormone support, or magnesium with melatonin for short-term sleep help. This makes it much easier to tell what’s actually working—and what’s not.

Check supplement quality and possible interactions

Not all supplements are created equal, especially during menopause. Look for brands that use third-party testing like NSF, USP, or GMP, and avoid products that hide dosing behind vague labels.

If you have conditions like PCOS, osteoporosis, clotting disorders, or a history of hormone-sensitive cancer, or if you’re taking prescription medications, always check with your doctor before starting new supplements. A quick conversation can help you stay safe and avoid unwanted side effects.

When To Talk To Your Provider

Supplements are meant to support your health, not silently replace medical care. Reach out to a professional if you:​

  • Have severe hot flashes, night sweats, mood changes, or sleep problems that disrupt daily life.

  • Notice unusual symptoms after starting a supplement, like chest pain, severe headaches, liver‑area pain, or allergic reactions.​

  • Are considering combining several herbal menopause formulas or high‑dose single supplements.

Used thoughtfully, supplements can be a gentle support system through every season—fertility years, perimenopause, and beyond—while you stay in the driver’s seat of your health!


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